Spravato FAQs

If you are struggling with symptoms of depression and still searching for treatment that works, you are not alone. While antidepressants are effective for some, many do not have success with this common treatment due to ineffectiveness or intolerable side effects. At Genesis Behavioral Health Services, our team understands how frustrating it can feel to try mental health treatments without success. We are here to support you with advanced methods that work when others have not. Spravato is an innovative product that has proven to be effective in restoring mental balance for those with treatment-resistant depression. After you review these Spravato FAQs, contact our team to schedule your consultation.

Is Spravato Safe?

Spravato uses ketamine-based therapy, and many patients have questions about whether this will be safe for them. Esketamine, the active ingredient in Spravato, received approval from the U.S. Food and Drug Administration (FDA) and remains subject to strict regulations to ensure its safety and effectiveness for eligible clients. The FDA first approved Spravato in 2019 as an adjunct therapy to antidepressants, and in 2025, expanded its approval to include use as a standalone treatment. As with any medical treatment, there may be certain risks to be aware of, depending on your medical history. Patients with high blood pressure, a history of brain bleeds or substance abuse, or those who are pregnant or breastfeeding may not be good candidates. Our team will answer your questions about Spravato candidacy and determine whether it is an appropriate treatment for you before scheduling sessions.

What Can You Expect From Treatment?

You can expect to self-administer Spravato via a nasal spray in our office. The frequency of your treatments follows a phase-based dosing schedule that begins with sessions twice a week for about a month, then gradually decreases based on response. You will be at our office for about two hours per treatment. During that time, one of our clinicians will monitor your mental and physical health to address any side effects that may arise. Feel free to ask us any questions about your esketamine treatment.

How Will You Feel After Treatment?

Esketamine is a sedative, which can make you feel temporarily drowsy, dizzy, or dissociated during or right after treatment. For safety reasons, you will need to arrange for someone to pick you up after each treatment. During your initial consultation, our providers can further detail the side effects of treatment and answer any remaining questions you have about Spravato.

Is Spravato Effective?

Several studies provide clinical backing for Spravato that, along with patient feedback, supports its widespread effectiveness in reducing symptoms of depression quickly and effectively, especially for those who have not responded to conventional therapies. Studies indicate that about 88% of patients who use Spravato experience noticeable improvement within three months, and some achieve complete symptom relief.

When Will You Feel Results?

One of the most unique features of Spravato compared to other depression treatments—and a common question from patients—is how quickly it can work. Many patients report symptom relief within just 24 hours of their first dose, and results improve as the treatment course continues. This fast-acting quality makes Spravato especially valuable for individuals dealing with severe depression, suicidal thoughts, or acute emotional distress. However, if you are experiencing a mental health emergency, it is important to seek immediate professional care to ensure your safety.

Contact Us if You Have More Questions About Spravato

If you are struggling with treatment-resistant depression or thoughts of harming yourself, Spravato can offer lifesaving relief. Now that you have reviewed these Spravato FAQs, reach out to our team at Genesis Behavioral Health Services to schedule an initial consultation and find out how this treatment can provide long-awaited relief and restore a sense of mental balance.
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